Emergence of Clostridium difficile tcdC variant 078 in Marseille, France

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Clostridium difficile 027 emerging outbreak in Marseille, France.

performed at the research laboratory (Director, Marcus Zervos, MD, PhD) of Henry Ford Hospital in Detroit, Michigan, and the research laboratory of Medical Center Utrecht (Director, Rob Willems, MD, PhD). Potential conflicts of interest. All authors report no conflicts of interest relevant to this article. All authors submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, a...

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Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078.

BACKGROUND Since 2005, an increase in the prevalence of Clostridium difficile infection (CDI) due to polymerase chain reaction ribotype 078 has been noticed in The Netherlands. This strain has also been identified as the predominant strain in pigs and calves. METHODS CDI caused by type 078 was studied in relation to CDI caused by the hypervirulent type 027 and by types other than 027 and 078....

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Clostridium difficile TcdC protein binds four-stranded G-quadruplex structures

Clostridium difficile infections are increasing worldwide due to emergence of virulent strains. Infections can result in diarrhea and potentially fatal pseudomembranous colitis. The main virulence factors of C. difficile are clostridial toxins TcdA and TcdB. Transcription of the toxins is positively regulated by the sigma factor TcdR. Negative regulation is believed to occur through TcdC, a pro...

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Evidence that Clostridium difficile TcdC is a membrane-associated protein.

Clostridium difficile produces two toxins, A and B, which act together to cause pseudomembraneous colitis. The genes encoding these toxins, tcdA and tcdB, are part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes. In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.

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Clostridium difficile in Ground Meat, France

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ژورنال

عنوان ژورنال: European Journal of Clinical Microbiology & Infectious Diseases

سال: 2017

ISSN: 0934-9723,1435-4373

DOI: 10.1007/s10096-017-3022-8